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DefinitionThis section has been translated automatically.
The APOA2 gene (APOA2 stands for: Apolipoprotein A2) is a protein coding gene located on chromosome 1q23.3.
General informationThis section has been translated automatically.
This gene encodes apolipoprotein (apo-) A-2, the second most abundant protein of high-density lipoprotein particles. The protein occurs in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D.
Diseases associated with APOA2 include:
- Hypercholesterolemia, familial, 1
and
- AapoA2 amyloidosis (apolipoprotein A2 amyloidosis; see also apolipoprotein A1 amyloidosis).
The encoded protein May stabilize high density lipoprotein (HDL) structure through its association with lipids and affect HDL metabolism.
LiteratureThis section has been translated automatically.
- Guo Z et al (2003) Amyloidosis modifier genes in the less amyloidogenic a/j mouse strain. Lab Invest 83:1605-1613.
- Horike K et al (2018) Two novel APOA1 gene mutations in a Japanese renal transplant recipient with recurrent apolipoprotein A-I related amyloidosis. Nephrology (Carlton) 23 Suppl 2:17-21.
- Jeraj N et al (2021) Apolipoprotein genetic variants and hereditary amyloidosis. Curr Opin Lipidol 32(2):132-140.
- Joy T et al (2003) APOA1 related amyloidosis: a case report and literature review. Clin Biochem 36:641-645.
