Antibodies against liver kidney microsome antigen$$$

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

LKM-AK

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DefinitionThis section has been translated automatically.

LKM antibodies (LKM is the acronym for "liver- kidney-microsome") recognize antigens of the cytochrome P450 system from liver and kidney. 3 different antigens can be defined: LKM-1 (Cytochrome P 450 IID6), LKM-2 (Cytochrome P 450 IIC9), LKM-3 (UDP-Gluronyltransferase). Anti-LKM antibodies (subclass LKM-1) are pathognomic for autoimmune hepatitis type 2.

ImplementationThis section has been translated automatically.

Test material: Serum

Method: IFT on kidney and liver tissue (screening test)

Immunoblot with mitochondrial or microsomal cytosolic antigens.

LiteratureThis section has been translated automatically.

  1. Böhm O (2018) Autoantibody diagnostics. In: Neumeier B et al. (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 424-425

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer