Antibodies against liver kidney microsome antigen $$$

LKM antibodies (LKM is the acronym for "liver- kidney-microsome") recognize antigens of the cytochrome P450 system from liver and kidney. 3 different antigens can be defined: LKM-1 (Cytochrome P 450 IID6), LKM-2 (Cytochrome P 450 IIC9), LKM-3 (UDP-Gluronyltransferase). Anti-LKM antibodies (subclass LKM-1) are pathognomic for autoimmune hepatitis type 2.

Test material: Serum

Method: IFT on kidney and liver tissue (screening test)

Immunoblot with mitochondrial or microsomal cytosolic antigens.

1. Böhm O (2018) Autoantibody diagnostics. In: Neumeier B et al. (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 424-425