Antacids

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Medicinal product for the treatment of complaints due to acidosis of the stomach.

For the most important antacids see Table 1.

IndicationThis section has been translated automatically.

In dermatology, antacids play a role in particular as concomitant medication in systemic therapies with glucocorticoids as well as immunosuppressive or cytostatic therapies.

Limited indicationThis section has been translated automatically.

Intestinal stenosis, hypophosphatemia, gastric outlet stenosis, renal insufficiency, constipation.

Undesirable effectsThis section has been translated automatically.

CNS disorders, anaemia, appetite disorders, constipation, osteomalacia (in dialysis patients), aluminium intoxication in long-term use.

InteractionsThis section has been translated automatically.

s. Table 2.

TablesThis section has been translated automatically.

Overview of the most important antacids and their dosage

Group/Active substance	Dosage	Finished preparation
Aluminium compounds
Aluminium hydroxide	3-4 times/day 2 tbl. p.o. after meals	Tepilta
Magnesium compounds
Magnesium carbonate	If required, chew or suck 1-2 tbl. finely	Palmicol
Aluminium-Magnesium Compounds
Hydrotalcite	1-2 h after the meals 2 tbl. p.o. each	Talcid
Magaldrate	4 times/day after meals 1-2 tbl. or 1 bag p.o.	Riopan
Carbaldrat	1-2 tbl/teel/btl. between meals and before bed	Compensation
Silicates
Aluminium magnesium silicopolyhydrate	Chew 2-3 tbl. intensively several times a day	Ultilac
Aluminium magnesium silicate hydrate	Suck or chew 1-2 tbl. several times a day	Gelusil
Combinations
Aluminium hydroxide-magnesium hydroxide	After the meals 1-2 tbl. or 1-2 bags p.o.	Maaloxan
Magnesium carbonate-calcium carbonate	If required 1-2 tbl., up to 3 times/day p.o.	Rennie
aluminium-magnesium-silicate hydrate + milk powder	Suck or chew 1-2 tbl. several times a day or dissolve and ingest the contents of 1-2 bags in ¼ glass of water	Gelusil-Lac

Significant interactions of antacids

Allopurinol	Allopurinol level ↓, take antacid 3 hours before allopurinol
Atenolol	Atenolol Mirrors ↓
Biphosphonates	Biphosphonate levels ↓
Chenodesoxycholic acid	Chenodesoxycholic acid levels ↓
quinine	quinine levels ↓
Cimetidine	Cimetidine level ↓, take in 2 hours intervals
Ciprofloxacin	Ciprofloxacin levels ↓
Iron	Iron Mirrors ↓
Cardiac glycosides	Glycoside levels ↓
Hydroxychloroquine	Hydroxychloroquine Mirror ↓, to be taken 4 hours apart
Isoniazid	Isoniazid mirror ↓
Itraconazole	Itraconazole level ↓, to be taken 2 hours apart
Ketoconazole	Ketoconazole level ↓, to be taken 2 hours apart
Misoprostol	Misoprostol levels ↓
Food	Fruit juices and wine increase toxicity of Al-containing antacids
Sodium fluoride	Sodium fluoride level ↓, take at intervals of 2 hours
Ofloxacin	Ofloxacin levels ↓
Propanolol	Propanolol levels ↓
Phenytoin	Phenytoin levels ↓
Rifampicin	Rifampicin levels ↓
Tetracyclines	Tetracycline level ↓, to be taken 3 hours apart
Ursodeoxycholic acid	Ursodeoxycholic acid levels ↓

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer