Angiotensinogen

Ohkubo et al. 1983

Angiotensinogen is a protein, a prohormone with 452 amino acids with a molecular weight of 49,761 Da. The coding gene is located on the long arm of chromosome 1 (Chr 1: 228.9 - 228.92 ). After translation by hepatocytes and transport to the liver cell membrane, the peptide angiotensin I , which consists of 10 amino acids, is cleaved off, the actual effective signal sequence. The resulting angiotensinogen is released into the plasma.

The angiotensinogen formed in the liver circulates in human blood plasma. During the electrophoretic separation of serum proteins, it migrates in the α2 globulin fraction.