Synonym(s)
Antibodies antimitochondrial; Antimitochondrial antibodies
DefinitionThis section has been translated automatically.
Acronym for "antimitochondrial antibodies" (autoantibodies against mitochondria). 9 subtypes against different mitochondrial AK (M1-M9) are known.
IndicationThis section has been translated automatically.
AMA titers are particularly elevated in primary biliary cirrhosis (Ak against M2: specificity: approx. 95%), in systemic scleroderma, CREST syndrome, polymyositis.
Increased titers are less frequent in antiphospholipid syndrome and lupus erythematosus .
An increase in AMA titre is also possible in syphilis II.
ImplementationThis section has been translated automatically.
Determination method:
IFT (Hep-2 cells) or prox. renal tubules.
ELISA: quatitaver detection
Immunoblot: Differentiation of the subunits M1-M9
Note(s)This section has been translated automatically.
- Determination from blood serum (blood sample required to obtain 5 ml serum). Standard value: titre < 1:10.
- In unclear cases, have AMA subtyping performed.
Prof. Dr. med. Peter Altmeyer