Synonym(s)
Acute phase proteins; Acute-phase proteins
DefinitionThis section has been translated automatically.
Proteins that are produced during an acute phase reaction (ARR) of the organism, mainly in the liver.
ClassificationThis section has been translated automatically.
The acute phase proteins include:
- C-reactive protein (CRP)
- Complement component C3
- Serum Amyloid A (SAA)
- human haptoglobin
- Fibrinogen
- alpha-1-antitrypsin
- Coeruloplasmin
Note(s)This section has been translated automatically.
The activation of the acute-phase reaction is mainly effected by cytokines. The endogenous pyrogens, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1 (IL-1), adjust the set point of the body temperature regulation in the hypothalamus. At the cellular level, leukocytosis occurs with left-shifting (effect of granulocyte-macrophage colony stimulating factor - GM-CSF), aggregation of platelets, edema and mast cell degranulation with release of mediators.
Prof. Dr. med. Peter Altmeyer