Synonym(s)
DefinitionThis section has been translated automatically.
17-beta-estradiol is the essential estrogen of the sexually mature woman, from the granulosa cells of the maturing follicle and in pregnant women in the placenta. 17-beta-estradiol is produced by aromatizing testosterone, but also estrone. The concentration of 17-beta-estradiol changes in the course of the female cycle. In males the production takes place in the testicles and the adrenal cortex.
General informationThis section has been translated automatically.
Standard values for women (standard values in pg/ml) - Conversion factor: pg/ml x 3.671 = pmol/l
- Prepubertal: < 20
- Early follicular: 20-190
- Preovulatory: 150-350
- Luteal: 100-200
- Postmenopausal: < 30
- Men: <40
- Pregnancy 1st Trimenon: 300-7.000
- Pregnancy 2nd Trimenon: 1.000-17.900
- Pregnancy 3rd Trimenon: 4.300-17.600
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IndicationThis section has been translated automatically.
Suspicion of cycle disorders
Assessment of ovarian function
Monitoring of follicle maturation (oocyte maturation)
Suspicion of oestrogen-producing tumours
Determination of the need for substitution during the menopause
Control of sterility therapy
ImplementationThis section has been translated automatically.
Determination methods: ECLIA; LIA; ID-GC/MS
Clinical pictureThis section has been translated automatically.
Interpretation: increased values in women
- Follicular persistence - absence of follicular sprouting with excessive hormone production
- Oestrogen-producing tumours (granulosa and thecacell tumour)
- Liver dysfunction such as cirrhosis (connective tissue remodelling of the liver with functional impairment) - Slowing down of the oestradiol metabolism
- renal dysfunction - slowing down of the oestradiol metabolism
- Estrogen substitution and overdose
- Periovulatory phase (phase around ovulation)
- Gravidity (pregnancy)
Interpretation: increased values in men
- Adiposity (obesity)
- Hormone producing tumors
- Liver dysfunction such as cirrhosis (connective tissue remodelling of the liver with functional impairment) - Slowing down of the oestradiol metabolism
- renal dysfunction - slowing down of the oestradiol metabolism
Interpretation: lowered values for women
- primary ovarian insufficiency
- Menopause
- Secondary ovarian insufficiency
- Taking hormonal contraceptives
- Lack of stimulation of the ovary
- Pituitary insufficiency: Corpus luteum insufficiency; anovulation
Note(s)This section has been translated automatically.
When interpreting the measured values, the phase of the cycle must always be taken into account (specify the day of the cycle on the day of blood collection or the first day of the last menstrual period).
LiteratureThis section has been translated automatically.
- Böhm C et al (2017) in: Neumeister B et al. clinical guide to laboratory diagnostics. Urban&Fischer Publisher Munich S. 341
Prof. Dr. med. Peter Altmeyer