
Addison's disease E27.1
Addison's disease: the palms of the previously described patient. pigmentation of the palm lines as well as the finger wrinkles. hyperpigmentation at traumatized areas typical for Addison's disease (here: calluses)
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Fixed drug eruption L27.1
Drug reaction, fixed: recurrent course with acute itchy redness 1 day after taking ibuprofen (600 mg) due to rheumatoid complaints. After 2-3 days the acute symptoms subsided with the residual hyperpigmentation shown here. The acute changes occurred strictly localized.

Acromegaly E22.0
Acromegaly: 43-year-old patient with known acromegaly. Noticeable increase in size of the lower extremities. Simultaneous development of excessive varicosis with consecutive chronic venous insufficiency (CVI).

Addison's disease E27.1
Addison's disease: clearly pigmented palm line patterns in otherwise normal palmar skin.