Spink1 gene

Authors:Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Guido Gerken

All authors of this article

Last updated on: 29.10.2020

Synonym(s)

Pancreatic secretory trypsin inhibitor; PSTI; SPINK1; TATI; Tumor-associated trypsin inhibitor

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DefinitionThis section has been translated automatically.

SPINK1 is the acronym for "serine protease inhibitor Kazal-type 1". The human SPINK1 gene spans about 7.5 kilobases of DNA on chromosome 5 and consists of four exons. SPINK1 encodes the SPINK1 protein, a protein product of 79 amino acids in length, a serine protease inhibitor (Kazal-type 1), also known as pancreatic secretory trypsin inhibitor (PSTI). Mutations in the SPINK1 gene are associated with hereditary pancreatitis (see below chronic pancreatitis).

Note(s)This section has been translated automatically.

Mutations in the SPINK5 gene are associated with Netherton syndrome.

Authors

Last updated on: 29.10.2020

Authors: Prof. Dr. med. Peter AltmeyerProf. Dr. med. Guido Gerken