Attenuated familial polyposisD12.6

Authors:Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Guido Gerken

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

AFAP; Familial polyposis, attenuated

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DefinitionThis section has been translated automatically.

The attenuated FAP (AFAP) is a milder form of FAP.

In AFAP, patients usually develop < 100 adenomatous polyps in the colon. The polyps develop about 10-15 years later than in classic FAP.

The polyps are mainly observed in the proximal (ascending) part of the colon.

Clinical featuresThis section has been translated automatically.

Only in about 20-30% of patients with a mild form of FAP is a germline mutation in the APC gene identified as the cause of polyposis (APC-associated AFAP). In many cases, the mutation is located in specific areas of the APC gene.

The APC-associated AFAP - like the classical FAP - is also inherited by children with a probability of 50% after autosomal dominant inheritance.

The degeneration risk of polyps in AFAP is also high. Therefore, early detection examinations are also very important in AFAP.

Authors

Last updated on: 29.10.2020

Authors: Prof. Dr. med. Peter AltmeyerProf. Dr. med. Guido Gerken