Synonym(s)
DefinitionThis section has been translated automatically.
The attenuated FAP (AFAP) is a milder form of FAP.
In AFAP, patients usually develop < 100 adenomatous polyps in the colon. The polyps develop about 10-15 years later than in classic FAP.
The polyps are mainly observed in the proximal (ascending) part of the colon.
Clinical featuresThis section has been translated automatically.
Only in about 20-30% of patients with a mild form of FAP is a germline mutation in the APC gene identified as the cause of polyposis (APC-associated AFAP). In many cases, the mutation is located in specific areas of the APC gene.
The APC-associated AFAP - like the classical FAP - is also inherited by children with a probability of 50% after autosomal dominant inheritance.
The degeneration risk of polyps in AFAP is also high. Therefore, early detection examinations are also very important in AFAP.
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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer
Prof. Dr. med. Guido Gerken