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DefinitionThis section has been translated automatically.
Zonula occludens proteins are peripherally associated cytoplasmic membrane proteins belonging to the membrane-associated guanylate kinase homologs (MAGUK) family. Three different MAGUKs have been identified: ZO-1, ZO-2 and ZO-3, with molecular weights of 220, 160 and 130 kDa, respectively. ZO-1, discovered in 1986, was the first member of the tight junction family to be identified (Stevenson BR et al. 1986).
