Xanthoma verruziformes

Shafer 1971

Probably traumatically induced, solitary, painless, xanthomatous neoplasm, which is preferably observed on the oral mucosa (especially hard palate or gingiva).

Probably multifactorial etiopathogenesis; often reactive after trauma; a traumatic relocation of surface epithelium into the lamina propria with uptake into then xanthomatous transformed macrophages is discussed. This thesis is unlikely for extraorally localized verrucous xanthomas.

Especially oral mucosa, especially hard palate, gingiva, scrotum, penis, vulva

Sharply defined, 0.2-2.0 cm large, exophytic (plaque, papule, nodules), firm, new formation with rough, usually wart-like surface. The colour may be greyish-white, reddish or yellowish. Ulceration of the surface possible.

Extraorally, there are single or multiple, symptomless, filiform or papular wart-like elevations of the skin, which are usually clinically diagnosed as viral acanthomas.

Plump acanthosis of the surface epithelium, hyperparakeratosis, in the lamina propria masses of foam cells with immune reactivity for adipophilin.

Excision or curettage

1. Beutler BD et al (2015) Verruciform Genital-Associated (Vegas) Xanthoma: report of a patient with verruciform xanthoma of the scrotum and literature review. Dermatol Online J 21 pii: 13030/qt7kb930rf.
2. de Andrade BA et al (2015) Oral verruciform xanthoma: a clinicopathologic and immunohistochemical study of 20 cases. J Cutan Pathol 42: 489-495.
3. Harris L et al (2015) Oral verruciform xanthoma. BMJ Case Rep pii: bcr2014209216.
4. Qi Y et al (2013) A case of multiple verruciform xanthoma in gingiva. Br J Oral Maxillofac Surgery 52:e 1-3.
5. Shaver WG (1971) Verruciform Xanthoma. Oral Surg Med Oral Pathol 31: 784-789
6. Sinnya S et al (2014) Verruciform xanthoma of the penis: a rare Australian case. Australas J Dermatol 56: e99-e101.