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Xanthogranuloma adultesD76.3

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 19.10.2022

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Synonym(s)

adult xanthogranuloma

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HistoryThis section has been translated automatically.

Gartmann and Tritsch, 1963

DefinitionThis section has been translated automatically.

Very rare, benign "granulomatous" disease of the non-Langerhans cell histiocytosis type occurring on skin and mucous membranes with coarse yellowish-reddish papules, plaques and nodules (for classification see xanthogranulomas).

LocalizationThis section has been translated automatically.

Face (periorbital region), neck, forearms; rarely in the genital region. Eye involvement with conjunctivitis, keratitis, scleritis or uveitis is possible.

Clinical featuresThis section has been translated automatically.

Solitary or oligolesional skin-colored, yellow or yellow-red, asymptomatic papules or nodules with a smooth surface. No spontaneous regression; no association with systemic disease.

HistologyThis section has been translated automatically.

Epidermis flattened, no epidermotropism. Dense infiltrates in papillary and reticular dermis consisting of histiocytes, foam cells, and giant Touton-type cells. Focal lymphohistiocytic infiltrates and neutrophilic and eosinophilic granulocytes. Frequent (30-40% of cases) infiltration of deeper tissues such as fascia and muscle.

Immunohistology: Stabilin-1(MS-1 HMWP)-positive and CD163-positive histiocytes; S100- and CD1a negative.

TherapyThis section has been translated automatically.

Excision of individual lesions, possibly CO2 laser therapy.

LiteratureThis section has been translated automatically.

  1. Boudhir H et al.(2013) Adult xanthogranuloma. Ann Dermatol Venereol 140:574-575
  2. Bourra H et al (2013) Adult xanthogranuloma at the base of the nose. Ann Dermatol Venereol 140:835-837
  3. Chisolm SS et al (2015) Adult Xanthogranuloma, Reticulohistiocytosis, and Rosai-Dorfman Disease. Dermatol Clin 33:465-472
  4. Kobayashi A et al (2002) Adult-onset limbal juvenile xanthogranuloma. Arch Ophthalmol 120: 96-97
  5. Li S et al (2016) Adult onset xanthogranuloma presenting as laryngeal mass.
    Am J Otolaryngol 37:112-115.
    seastrom Set al. (2014) Necrobiotic xanthogranuloma without a monoclonal gammopathy. Cutis 94:293-296
  6. Sueki H et al (1995) Adult-onset xanthogranuloma appearing symmetrically on the ear lobes. J Am Acad Dermatol 33: 372-374
  7. Tan LC et al (2014) Unusual presentation of adult xanthogranuloma: a case report. Singapore Med J 55(:e25-27)

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Last updated on: 19.10.2022

Author: Prof. Dr. med. Peter Altmeyer