Vitamin d hypervitaminosisE67.3
Synonym(s)
Vitamin D Hypervitaminosis; Vitamin D hypervitaminosis, vitamin D overdose; vitamin d overdosage
DefinitionThis section has been translated automatically.
Excessive intake of vitamin D accompanied by an increase in serum calcium levels. Vitamin D intoxication is usually observed only at serum 25(OH)D levels above 150ng/ml (374nmol). However, there is evidence that levels > 60ng/ml have an adverse effect on certain chronic diseases.
EtiopathogenesisThis section has been translated automatically.
Usually triggered by drug intake and simultaneous calcium-rich diet.
Clinical featuresThis section has been translated automatically.
Headache, fatigue, hypertension, polyuria, calcinosis metastatica.
TherapyThis section has been translated automatically.
Discontinue vitamin D substitution. Low calcium diet (no dairy products!). Treatment of hypercalcemia. Forced diuresis with 2-3 l of physiological (0.9%) NaCl solution, with addition of furosemide and potassium if necessary. Systemic administration of glucocorticoids, clodronic acid (e.g., Bonefos) and, if necessary, hemodialysis are further therapeutic options. Cooperation with the internist.
LiteratureThis section has been translated automatically.
- KO ML et al (1991) Chronic Vitamin D overdosage: a reminder. Arch Dis Child 66 (8) 1002