Vitamin a hypervitaminosisE67

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Disease pattern in acute or chronic overdose of vitamin A. Normal vitamin A daily requirement: 5.000 IU/day.

Clinical featuresThis section has been translated automatically.

  • Acute: Nausea, headache, followed by skin flaking.
  • Chronic: weight loss, anorexia, lethargy, dry, irritable skin (xerosis), mucosal rashes, diffuse telogenic effluvium.

LaboratoryThis section has been translated automatically.

Transaminases and alkaline phosphatase are elevated.

Differential diagnosisThis section has been translated automatically.

Seborrheic eczema; pellagra; eczema, contact dermatitis.

TherapyThis section has been translated automatically.

Stopping the vitamin A supply, including external or internal therapy with vitamin A acid preparations

External therapyThis section has been translated automatically.

Blande fattening therapy with the addition of urea if necessary (e.g. Nubral cream, Basodexan cream, Excipial U-Lipolotio, R102, R104 ).

LiteratureThis section has been translated automatically.

  1. Hamann K et al (1982) Chronic hypervitaminosis A with skin lesions. Dermatologist 33: 559-561
  2. Lips P (2003) Hypervitaminosis A and fractures. N Engl J Med 348: 347-349
  3. Muggia FM (1992) Vitamin A Intoxication during taxol therapy for refractory ovarian cancer J Natl Cancer Inst 18: 1444-1445
  4. Perrotta S et al (2003) Vitamin A and infancy. Biochemical, functional, and clinical aspects. Vitamin Horm 66: 457-591

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer