Vitamin a hypervitaminosis E67

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Disease pattern in acute or chronic overdose of vitamin A. Normal vitamin A daily requirement: 5.000 IU/day.

Clinical features
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  • Acute: Nausea, headache, followed by skin flaking.
  • Chronic: weight loss, anorexia, lethargy, dry, irritable skin (xerosis), mucosal rashes, diffuse telogenic effluvium.

Laboratory
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Transaminases and alkaline phosphatase are elevated.

Differential diagnosis
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Therapy
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Stopping the vitamin A supply, including external or internal therapy with vitamin A acid preparations

External therapy
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Blande fattening therapy with the addition of urea if necessary (e.g. Nubral cream, Basodexan cream, Excipial U-Lipolotio, R102, R104 ).

Literature
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  1. Hamann K et al (1982) Chronic hypervitaminosis A with skin lesions. Dermatologist 33: 559-561
  2. Lips P (2003) Hypervitaminosis A and fractures. N Engl J Med 348: 347-349
  3. Muggia FM (1992) Vitamin A Intoxication during taxol therapy for refractory ovarian cancer J Natl Cancer Inst 18: 1444-1445
  4. Perrotta S et al (2003) Vitamin A and infancy. Biochemical, functional, and clinical aspects. Vitamin Horm 66: 457-591

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020