HistoryThis section has been translated automatically.
Esterly 1977
DefinitionThis section has been translated automatically.
Probably autosomal dominant inherited syndrome of eruptive adnexal tumors with hair follicle differentiation. Eruptive vellus hair cysts can occur in association with Steatocystoma multiplex as well as with Pachyonychia congenita.
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EtiopathogenesisThis section has been translated automatically.
Probably autosomal-dominant inherited and spontaneous mutations of the gene KRT17, which is localized on the gene locus 17q12-q21 and leads to consecutive disorders of keratin 17, especially in the nail bed, hair follicles and in sebaceous glands. S.a.u. Steatocystoma multiplex (in this syndrome a KRT17 mutation has also been proven - some authors suspect identity of both diseases).
ManifestationThis section has been translated automatically.
Usually already occurs in childhood.
LocalizationThis section has been translated automatically.
It's mainly located on the torso, especially the chest area. Also occurring on the face (cheeks and nose) and on the extremities.
Clinical featuresThis section has been translated automatically.
Disseminated, very rarely solitary, asymptomatic, 0.1 to 1.0 cm large, skin-coloured papules.
HistologyThis section has been translated automatically.
Small cysts lined with squamous epithelium which can cornify both trichilemmal and epidermal. In the cyst lumen loosely layered horn material and numerous incisions of small hairs. Remains of a follicle can be found at the base of the cyst.
TherapyThis section has been translated automatically.
Surgical intervention often brings cosmetically unsatisfactory results. Try diathermy orCO2 laser treatment.
LiteratureThis section has been translated automatically.
- Esterly NB et al (1977) Eruptive vellus hair cysts. Arch Dermatol 113: 500-503
- Hayashibe K et al (1986) Eruptive vellus hair cysts: first case of onset in middle age. Arch Dermatol 122: 141
- Reep MD et al (2002) Eruptive vellus hair cysts presenting as multiple periorbital papules in a 13-year-old boy. Pediatric Dermatol 19: 26-27
- Tomkova H et al (1997) Expression of keratin (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. At J Dermatopathol 19: 250-253
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Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer