DefinitionThis section has been translated automatically.
Uteroglobin, was first described by Beier in 1966 as an uterine secretion product in rabbits.
Uteroglobin is also known as SCGB1A1 (secretoglobulin family 1A memeber 1) and is a member of the secretion globin family, small dimeric proteins found only in mammals.
The physiological role of uteroglobulins is not yet known. The mammaglobin, a glycoprotein with homology to the uteroglobilin family, is a marker for breast cancer. Further assumptions are: immunomodulation, influence on the fibronectin function.
Uteroglobulin knockout mice develop a good-pasture syndrome.
SCGB1A1 was identified molecularly as Fel d 1; Fel d 1 is the major allergen of the cat.
LiteratureThis section has been translated automatically.
- Grönlund H et al (2009) The major cat allergen, Fel d 1, in diagnosis and therapy. Int Arch Allergy Immunol 151:265-274.
- Kaiser L et al (2007) Structural characterization of the tetrameric form of the major cat allergen Fel d 1 J Mol Biol 370:714-727.