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Umbilical metastasisC79.2

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 31.08.2024

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Synonym(s)

Metastasis umbilical; Sister Joseph\'s Nodule; Sister Joseph's Nodules; umbilical metastasis

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HistoryThis section has been translated automatically.

Bailey 1949

DefinitionThis section has been translated automatically.

Rare form of a skin metastasis, usually originating from internal adenocarcinomas (stomach, ovaries, colon/rectum, pancreas). Metastasis per continuitatem is possible in peritoneal carcinomatosis, via umbilical vessels or via embryonic structures (urachus).

Clinical featuresThis section has been translated automatically.

Rough, reddened, occasionally painful, on average 1-2 cm large lump with mostly intact, but possibly ulcerated surface. Occurs mostly in the late stage of the underlying tumor disease, but sometimes also as the first clinically detectable symptom.

Differential diagnosisThis section has been translated automatically.

Umbilical calculus formation; melanocytic nevus; lipoma; hemangioma; cutaneous endometriosis; carcinoma; omphalomesenteric duct cyst.

TherapyThis section has been translated automatically.

The aim of treatment is to maintain the best possible quality of life despite an unfavorable prognosis. Individual skin metastases can be excised; radiotherapy or cytostasis are possible for extensive metastases. The treatment regimen depends on the spread of the metastases. In the case of initial symptoms, the focus is on clarification and treatment of the primary tumor.

Progression/forecastThis section has been translated automatically.

Usually unfavorable, also depending on the primary tumor.

Note(s)This section has been translated automatically.

The name refers to the surgical nurse Mary Joseph, who observed the occurrence of an umbilical node in an intra-abdominal malignancy in a hospital in Rochester, Minnesota. Hamilton Bailey named this rare metasis pathway in her honor.

LiteratureThis section has been translated automatically.

  1. Bailey H (1949) Demonstrations of physical signs in clinical surgery. Williams and Wilkins, Baltimore
  2. Bork K et al. (2002) Umbilical metastasis of a gallbladder carcinoma: "Sister Mary Joseph's nodule". Dtsch Med Wochenschr 127: 553-556
  3. Boyde AM et al. (2003) Sister Mary Joseph's nodule in malignant peritoneal mesothelioma. Histopathology 43: 303-304
  4. Clements AB (1952) Metastatic carcinoma of umbilicus. JAMA 150: 556-559
  5. Holzki G et al. (1989) "Sister Joseph's module"--umbilical metastases of internal tumors. Dermatology 40: 312-315
  6. Ishizawa T et al. (1997) Sister Joseph's nodule: a case report and review of the Japanese literature. J Dermatol 24: 662-665
  7. Ständer S et al (2016) Spontaneously occurring livid nodule in the navel. Dermatologist 67: 500-502
  8. Tam C et al. (2002) Diffuse large B-cell non-Hodgkin's lymphoma presenting as Sister Joseph's nodule. Leuk Lymphoma 43: 2055-2057
  9. Hugen N et al. (2021) Umbilical metastases: Real-world data shows abysmal outcome. Int J Cancer ;149:1266-1273. doi: 10.1002/ijc.33684. Epub 2021 May 25. PMID: 33990961; PMCID: PMC8361932

Authors

Last updated on: 31.08.2024

Author: Prof. Dr. med. Peter Altmeyer