DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
10, 11 hours.
You might also be interested in
Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of folic acid biosynthesis by inhibition of dihydrofolic acid reductase.
Spectrum of actionThis section has been translated automatically.
Gram positive and negative aerobic bacteria, Plasmodium spp. and Pneumocystis carinii.
IndicationThis section has been translated automatically.
Infections with gram-negative germs, malaria, Pneumocystis carinii pneumonia.
Dosage and method of useThis section has been translated automatically.
- Adults/young people > 12 years: 2 times/day 150-200 mg p.o.
- Children < 12 y. 2 times/day 3 mg/kg bw p.o.
- Pneumocystis carinii pneumonia: 4-5 mg/kg bw/6 hours in combination with sulfamethoxazole 20-25 mg/kg bw/6 hours over 2-3 weeks.
Notice! For long-term therapy: megaloblast anaemia (can be compensated by the administration of folic acid).
Undesirable effectsThis section has been translated automatically.
- Cutaneous reactions up to toxic epidermal necrolysis, angioedema, fixed drug reactions.
- Extracutaneous: nausea, vomiting, diarrhoea, BB changes.
InteractionsThis section has been translated automatically.
Increase of the phenytoin level.
ContraindicationThis section has been translated automatically.
Pregnancy, nursing.
PreparationsThis section has been translated automatically.
Infectotrimet, TMP-ratiopharm
Prof. Dr. med. Peter Altmeyer