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Trichoepithelioma, desmoplasticD23.L

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.01.2021

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Synonym(s)

Hamartoma epithelial sclerosing; Sclerosing epithelial hamartoma

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DefinitionThis section has been translated automatically.

Adnexal tumour of the skin with follicular differentiation close to the conventional trichoepithelioma , which differs from the trichoepithelioma by a distinct fibrotic tumour stroma. Its histological differentiation from sclerodermiform basal cell carcinoma is important. See also adnexal tumours with hair follicle differentiation.

ManifestationThis section has been translated automatically.

Occurs mainly with young women.

LocalizationThis section has been translated automatically.

Preferably located in the face.

Clinical featuresThis section has been translated automatically.

Asymptomatic, sunken, 0.3-0.8 cm large, reddish to yellowish, not ulcerating, coarse nodule with raised edges.

HistologyThis section has been translated automatically.

Traits of epithelial, basaloid cells, horny cysts and calcifications in dense, cell-poor, fibrotic (desmoplastic) connective tissue. Clearly distinguishable from normal connective tissue. Foreign body granulomas, ruptured epithelial cysts and calcifications are detectable.

Differential diagnosisThis section has been translated automatically.

TherapyThis section has been translated automatically.

Surgical removal, with microscopically controlled surgery for infiltrating variants.

LiteratureThis section has been translated automatically.

  1. Brownstein MH, Shapiro L (1977) Desmoplastic trichoepithelioma. Cancer 40: 2979-2986
  2. Dammert J et al (1987) Desmoplastic trichoepithelioma. Dermatologist 38: 603-606
  3. Karimzadeh I et al (2018) Trichoepithelioma: A Comprehensive Review. Acta Dermatovenerol Croat 26:162-165.
  4. Koay JL et al (2002) Asymptomatic annular plaque of the chin: desmoplastic trichoepithelioma. Arch Dermatol 138: 1091-1096.
  5. Niimi Y et al (2002) Desmoplastic trichoepithelioma: the association with compound nevus and ossification. Eur J Dermatol 12: 90-92
  6. Rahman J et al (2020) Desmoplastic trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors. Cureus 12:e9703.
  7. Yamamoto O et al. (2002) Immunohistochemical and ultrastructural observations of desmoplastic trichoepithelioma with a special reference to a morphological comparison with normal apocrine acrosyringeum. J Cutan Pathol 29: 15-26

Authors

Last updated on: 29.01.2021

Author: Prof. Dr. med. Peter Altmeyer