Triamcinolone acetonide

Moderately effective (class II) glucocorticoid halogenated with fluorine which is suitable as a topical agent for short-term skin therapy.

Like other glucocorticoids, trimacinolone acetonide has anti-inflammatory, immunosuppressive, antipruriginous and antiproliferative effects.

• Topical: Cream/Ointment/Spray/Lotion: Apply 1-2 times/day thinly to the affected skin areas.

  Remember!

  Duration of application max. 4 weeks!
• Injection: 0,5-1 ml intrafocal, intraarticular, sublesional.

Side effects on triamcinolone acetonide are very rare. The DKG has tested triamcinolone acetonide 0.1% in Vasline so far. This application form is no longer available as a test substance in Germany. Therefore, a 1% concentration of triamcinolone acetonide in Vaseline is now (as of 2016) recommended.

R262 R263 R259 R260 R261

• The optimum pH stability is pH7 and harmonizes with that of Clotrimazole, for example. Triamcinolone acetonide is insoluble in water and moderately soluble in ethanol (5 in 100). Alkaline and acidic active ingredients and auxiliaries lead to hydrolytic cleavage (acetonide residue is split off = 90% loss of effectiveness). Combinations with (weakly basic) zinc oxide lead to slow hydrolytic and oxidative decomposition (shelf life must be limited to 4 months).
• For the treatment of skin diseases at difficult locations the active ingredient is available as a spray (Polcortolon N Spray).
• According to recent extensive studies, intramuscular administration can no longer be considered obsolete. It is a properly performed alternative for severe inflammatory skin diseases or allergies (Østergaard MS et al. 2005).

1. Geier J et al (2016) News on the epicutaneous test series of the German Contact Allergy Group. Dermatology at work and in the environment 64: 70-75

2. Østergaard MS (2005) Hay fever and a single intramuscular injection of corticosteroid: A systematic review. Primary Care Respiratory Journal 14:124-30