Tinidazole

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Chemotherapeutic agent of the imidazole type.

Half-life
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8-13 hours.

Indication
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Infections with anaerobes (Bacteroides, Fusobacteria) and protozoa (Trichomonas vaginalis, Entamoeba histolytica).

Limited indication
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Pregnancy, lactation, BB changes, long-term therapy, severe liver damage, CNS disease.

Dosage and method of use
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  • Anaerobic infection: 0,15 g twice a day for 7 days or ED of 2 g.
  • Trichomoniasis, Lambliasis: 2 g as ED.
  • Amoebiasis: 2 g/day p.o. for 2-3 days for intestinal and 3-5 days for liver infection.

Undesirable effects
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Allergic reactions, serum sickness, potential carcinogen, headache, depression, agitation, metallic taste, leukopenia, gastrointestinal disorders, dark discoloration of urine, arthralgia.

Interactions
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Reduced alcohol tolerance, increased bleeding tendency when taking coumarins.

Contraindication
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Imidazole hypersensitivity, children < 12 years.

Preparations
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Simplotan

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Last updated on: 29.10.2020