Tiabendazole

Author: Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

Synonym(s)

Thiabendazole; Tiabendazole 10%-Betamethasone 01%-Ointment; Tiabendazole ointment 10%

Definition
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Systemic anthelmintic. Topically it can be applied to Larva migrans.

Tiabendazole is approved in the EU under number E 233 as a food additive (preservative). The substance is only used externally on peels of citrus fruits.

Half-life
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10–12 h

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Spectrum of action
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Ancylostoma brasiliense, Angiostrongylus cantonensis and costaricensis, Capillaria philippinensis, Dracunculus medinensis, Stronyloides fuelleborni and stercoralis, Toxocara spp.

Indication
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Systemic use: Infections with nematodes. Topical use: for Larva migrans.

Dosage and method of use
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See table

Standard concentration
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2-10% in solutions or creams.

Undesirable effects
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In case of systemic application: nausea, vomiting, dizziness, hypotension, liver dysfunction, leukopenia, crystalluria, allergic reactions, hallucinations, odour disorders. Very rarely shock, ringing in the ears, erythema exsudativum multiforme.

Interactions
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With simultaneous administration of allopurinol or theophylline, increase in xanthine metabolites or theophylline levels.

Contraindication
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Pregnancy, liver and kidney failure, hypersensitivity.

Recipe(s)
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Tiabendazole 10%-Betamethasone 0,1%-cream (O/W) R254

Tiabendazole 2% in DMSO solution

R252

Preparations
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Mintezol (available through the international pharmacy)

Tables
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Doses of Tiabendazole for infections with various pathogens

Indication	Dosage
ancylostoma brasiliensis	2 times/day 25 mg/kg bw p.o. over 3 days
angiostrongylus cantonensis	2 times/day 25 mg/kg bw for 7 days
angiostrongylus costaricensis	3 times/day 75 mg/kg bw over 3 days
capillaria philippensis	once/day 25 mg/kg bw for 4 weeks
Dracunculus medinensis	2 times/day 25 mg/kg bw for 3 days
Strongyloides fuelleborni	2 times/day 25 mg/kg bw for 3-5 days
Strongyloides stercoralis	2 times/day 25 mg/kg bw over 3-5 days, possibly up to 3 weeks
Toxocara spp.	2 times/day 25 mg/kg bw for 5-7 days
Trichinella	2 times/day 25 mg/kg bw (max. 3 g/day) over 7 days
Trichostrongylus	2 times/day 25 mg/kg bw for 5 days