Tenofovir

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 26.10.2024

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Definition
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Virustatic agent (nucleotide analogue). A nucleotide inhibitor of the reverse transcriptase of HIV.

Half-life
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12-18 hours.

Indication
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Antiretroviral combination therapy for the treatment of HIV-1 infection in treatment-naive or previously treated patients. Also approved as a combination preparation with emtricitabine (FTC) for HIV-PrEP.

Pregnancy/nursing period
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Strict indication in pregnancy (insufficient data), contraindicated in lactation (preparation passes into breast milk and insufficient data).

Dosage and method of use
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Adults/young people > 18 years: 1 time per day 1 tbl. p.o. with a meal. In case of swallowing difficulties, take the tablet dissolved in at least 100 ml of water, orange or grape juice.

Undesirable effects
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Very often light or moderate gastrointestinal complaints (nausea, diarrhoea, vomiting, flatulence).

Interactions
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Drugs whose active secretion in the kidney takes place via anion transporters (e.g. cidofovir), lopinavir/ritonavir, didanosine.

Contraindication
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Pat. < 18 years, hypersensitivity to Tenofovir or other components of the preparation.

Preparations
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Viread

Outgoing links (2)

Hiv infection; Virustatics;

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Last updated on: 26.10.2024