Tazobactam/piperacillin

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

piperacillin/tazobactam

Definition
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Combination preparation of the β lactamase inhibitor tazobactam with piperacillin.

Half-life
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1 h

Spectrum of action
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S.u. piperacillin, especially strains of bacteria containing β-lactamase.

Indication
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Infections by piperacillin-sensitive and resistant pathogens, if the resistance is based on the formation of β lactamases

Dosage and method of use
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9-13.5 g/day i.v. in 2-3 ED.

Undesirable effects
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Occasionally: Candida superinfection, leuko-, neutro-, thrombocytopenia.

Interactions
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Increase of neuromuscular blockade of muscle relaxants, increased bleeding tendency when using acetylsalicylic acid, s.a. benzylpenicillin.

Contraindication
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Penicillin allergy, infectious mononucleosis and other viral infections (increased risk of exanthema!), leukemia, pregnancy, lactation, children < 12 years.

Preparations
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Tazobac

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Piperacillin/tazobactam;

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Last updated on: 29.10.2020