Syringome disseminated D23.L

Benign, naevoid tumours (hamartomas) of the sweat gland with ductal (eccrine / apocrine) differentiation.

Preferably affected are women in the 2nd to 3rd decade of life.

Basically, syringomas can occur at all parts of the body surface, especially when they occur eruptively. Preferably they are found on the lower eyelids, less frequently on the upper eyelids (eyelid syringoma). Further on the neck, chest, axillary folds, groin, vulva/scrotum rarely on the extremities. Palms and soles of the feet are always left out. The acrally localized syringomas can usually be assigned to an eccrine origin.

Mostly multiple, disseminated, slowly developing over the years, less frequently erupting, about 0.2-0.3 cm large, firm, shifting, skin-coloured or reddish-brownish, completely symptom-free (milia-like) papules. They are primarily a cosmetic problem.

If cosmetically disturbing, excision may be necessary. Attempt of removal with ablative laser (Brightman L et al. 2011).

Further progression with appearance of new nodules. However, this is no indication of malignancy. The size of the nodules is self-limiting (<0.3 cm).

1. Bouyahyaoui Y et al. (2012) Generalized eruptive syringoma]. Ann Dermatol Venereol 139:508-509

2. Brightman L et al (2011) Commentary: treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser. Dermatol Surgery 37:439-44

3. Guitart J et al (2003): Eruptive syringoma, a misnomen for a reactive eccrine gland ductal proliferation? J Cutan Pathol 30: 202-205e

4. Jacobs S et al (2004) Disseminated eruptive syringomas in Down syndrome. Dermatologist 55:70-72.
5. Lee AY et al (1992) Generalized eruptive syringoma. J Am Acad Dermatol 25: 570-571
6. Tatsuno K et al (2011) Eruptive milium-like syringoma showing eccrine duct origin of milia. J Dermatol 39:878-679