Inflammatory skin and/or mucous membrane changes in the secondary and tertiary stages of acquired syphilis.
The secondary period (syphilis II) is characterized by intermittent, asymptomatic (no or only slight itching), macular exanthema, which can have a very different clinical morphology (acneiform, anular, bullous, lichenoid, pustular, etc.).
With increasing duration of the disease, increasing infiltration of the still asymptomatic efflorescences is typical (maculo-papular exanthema - papular exanthema - see syphilis acquisita below).
In the changes of the tertiary period (syphilis III), the symmetrically arranged appearance of the early syphilides is lost and is characterized by mostly large, mostly asymmetrically localized, yellow-brown or brown plaques or nodules