Sulbactam/ampicillin

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

ampicillin/sulbactam

Definition
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Combination preparation of the β lactamase inhibitor sulbactam with ampicillin.

Half-life
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1 h

Indication
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Infections by ampicillin-sensitive and -resistant pathogens, if the resistance is based on the formation of β-lactamases

Limited indication
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Pregnancy, lactation, newborns and infants.

Dosage and method of use
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  • Adults: 4-12 g/day i.v. or i.m. in 3-4 ED
  • Children and infants from the 2nd week: 150 mg/kg bw/day i.v. in 3-4 doses i.v. or i.m.

Interactions
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Attenuation of the effect of aminoglycosides, metronidazole, noradrenaline, prednisolone, procaine, tetracyclines and thiopental, see also benzylpenicillin.

Contraindication
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Penicillin allergy, infectious mononucleosis and other viral infections (increased risk of exanthema!), lymphatic leukemia.

Preparations
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Unacid

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Ampicillin/sulbactam;

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Last updated on: 29.10.2020