Synonym(s)
Adiponecrosis subcutanea neonatorum; Adiposclerosis symmetrical; fat tissue necrosis, subcutaneous of the newborn; subcutaneous fat necrosis of the newborn; Subcutaneous fat necrosis of the newborn; Symmetrical fatty sclerosis
HistoryThis section has been translated automatically.
Cause 1875
DefinitionThis section has been translated automatically.
2-3 days after birth, often symmetrical fatty sclerosis.
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EtiopathogenesisThis section has been translated automatically.
Heterogeneous. Consequence of traumatisation of the subcutaneous fatty tissue at birth, perinatal asphyxia or meconium aspiration.
LocalizationThis section has been translated automatically.
Mainly shoulder and buttock region, cheeks, proximal extremities.
Clinical featuresThis section has been translated automatically.
Brownish or blue-red, coarse, well defined, deep-seated, hardly shiftable, large, pressure indolent nodules or plate-like hardenings which appear 1-3 weeks after birth of the otherwise healthy infants. After initial manifestation often increasing for several weeks or months, then spontaneously involuting.
HistologyThis section has been translated automatically.
Lobular panniculitis with fatty tissue necrosis. Mostly alternating dense infiltrates of clustered foam cells and multinucleated giant cells with radial "needle shaped clefts". Fibroblasts in varying numbers. The needle-like, optically empty spaces correspond to dissolved fatty acid crystals. Rare occurrence of calcifications.
DiagnosisThis section has been translated automatically.
Clinic, histology, regular calcium checks
Differential diagnosisThis section has been translated automatically.
Sclerema adiposum neonatorum (poor prognosis, rapid progressive course; histological difference: no significant inflammatory features).
Complication(s)This section has been translated automatically.
Often hypercalcemia. Rarely septic softening.
TherapyThis section has been translated automatically.
Symptomatic; if necessary, rehydration, baths, heat, cotton wool bandages, avoidance of further mechanical stress.
Progression/forecastThis section has been translated automatically.
Recovery after several weeks to months without significant residual lipatrophies.
LiteratureThis section has been translated automatically.
- Bachrach LK (1999) Etidronate in subcutaneous fat necrosis of the newborn. J Pediatr 135: 530-531
- Burden AD et al (1999) Subcutaneous fat necrosis of the newborn: a review of 11 cases. Pediatric Dermatol 16: 384-387
- Norton AI (1997) Subcutaneous fat necrosis of the newborn: CT findings of head and neck involvement. At J Neuroradiol 18: 547-550
- Repiso-Jimenez JB (1999) Subcutaneous fat necrosis of the newborn. J Eur Acad Dermatol Venereol 12: 254-257
- Tran JT et al (2003) Complications of subcutaneous fat necrosis of the newborn: a case report and review of the literature. Pediatric Dermatol 20: 257-261
- Varan B (1999) Subcutaneous fat necrosis of the newborn associated with anemia. Pediatric Dermatol 16: 381-383
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Incoming links (7)
Adiponecrosis subcutanea neonatorum; Adiposclerosis, symmetrical; Cold panniculitis; Fat necrosis, subcutaneous of the newborn; Newborns, skin changes; Sclerema adiposum neonatorum; Subcutaneous fat necrosis of the newborn;Outgoing links (1)
Sclerema adiposum neonatorum;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer