Steroid 21-hydroxylase autoantibodies

Antibodies against steroid 21-hydroxylase, which occur mainly in Addison's disease (E27.1) with autoimmune etiology (approx. 80% of cases) and in autoimmune polyendocrinopathies (E31.0) and are of great diagnostic importance for these diseases.

The antibody titers show no correlation to the course of the disease.

If NNR antibodies are present, additional tests for marker antibodies (e.g. against thyroid, parathyroid, pancreas, and other organ-specific antibodies) may be indicated. Determination from serum, EDTA or heparin plasma.

1. Bansal S et al (2015) Presence of 21-hydroxylase Antibodies in a Boy with X-Linked Adrenal Hypoplasia Congenita. Horm Res Paediatr 84:408-413.
2. Dörr HG et al (2018) Mortality in children with classic congenital adrenal hyperplasia and 21-hydroxylase deficiency (CAH) in Germany. BMC Endocr Disord 18:37.