Stavudin

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

D4T

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DefinitionThis section has been translated automatically.

Virustatic.

Half-lifeThis section has been translated automatically.

3 h

Pharmacodynamics (Effect)This section has been translated automatically.

Nucleoside analogue, competitive inhibitor of the reverse transcriptase of HIV.

IndicationThis section has been translated automatically.

Combination therapy for HIV infection. AZT and stavudine have an antagonistic effect and are therefore not administered simultaneously.

Notice! The liquor flow is comparable to that of AZT.

Limited indicationThis section has been translated automatically.

Peripheral neuropathies in the medical history.

Dosage and method of useThis section has been translated automatically.

  • KG > 60 kg: 2 times 40 mg/day p.o.
  • KG < 60 kg: 2 times 30 mg/day

Undesirable effectsThis section has been translated automatically.

Peripheral neuropathy, pancreatitis, nausea, vomiting, diarrhea, headaches, sleep disorders, allergic exanthema, transaminase elevations.

Notice! Close monitoring of patients. In case of peripheral neuropathy, discontinue use immediately.

InteractionsThis section has been translated automatically.

Isoniazid, vincristine and zalcitabine increase the risk of peripheral neuropathies.

PreparationsThis section has been translated automatically.

Zerit

Merken! Patient information: Education about symptoms of peripheral neuropathy before starting therapy!

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer