Splendore-hoeppli phenomenon

Splendore, 1908

Histological phenomenon found both in humans (e.g. botryomycosis) and in various animal species in association with organic or inorganic substances. Morphologically, "pseudoactinomycotic" eosinophilic precipitates around organic (e.g. fungal spores) or inorganic foreign materials are found.

This phenomenon was first described in 1908 by Splendore in sporotrichosis. Later Hoeppli described the phenomenon in schistosomiasis.

1. Choon SE et al (2012) Conidiobolomycosis in a young Malaysian woman showing chronic localized fibrosing leukocytoclastic vasculitis: a case report and meta-analysis focusing on clinicopathologic and therapeutic correlations with outcome. At J Dermatopathol 34: 511-522
2. Kang JW et al (2010) Intranasal mycetoma-induced splendore-oeppliphenomenon. Otolaryngol Head Neck Surg 142:456-457
3. Liber AF et al (1973) Splendore-Hoeppli phenomenon about silk sutures in tissue. Arch Pathol 95: 217-220
4. Völcker HE et al (1985) Eosinophilic, central necrotizing granuloma of the conjunctiva (Splendore-Hoeppli phenomenon). Clinical-histopathological study. Clin Monbl Ophthalmology 186: 254-258