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SpiradenomaL74.8

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Spiradenocylindrome; Spiradenoma eccrines

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HistoryThis section has been translated automatically.

Hellwig and Kersting, 1956

DefinitionThis section has been translated automatically.

Rare, undifferentiated or slightly differentiated, benign (apparently pluripotent) adnexal tumor with predominantly eccrine differentiation. Apocrine, occasionally follicular differentiation is possible. Against the (exclusively) eccrine genesis speaks the observation that spiradenomas occur very rarely on the palms of the hands and soles of the feet.

ManifestationThis section has been translated automatically.

Mostly occurring in 20- to 40-year-old adults.

LocalizationThis section has been translated automatically.

Especially the head, neck, upper torso or sides of the arms are affected.

Clinical featuresThis section has been translated automatically.

Usually solitary, round, 0.5-3 cm large, coarse, skin-coloured to livid red, sharply defined, rarely spontaneously or under pressure painful tumour with a smooth surface. Multiple, disseminated or linearly arranged tumours are rare. The clinical picture is, apart from the possible painfulness, not very characteristic. The diagnosis is usually a histological accidental finding.

HistologyThis section has been translated automatically.

Very distinct histological morphology. Nodular tumour complex located in the deep dermis and surrounded by a fibrous connective tissue capsule, partly consisting of one or more nodes. The parenchyma consists of basaloid, poorly differentiated cell complexes. Detection of centrally located cells with large, pale nuclei and slightly basophilic cytoplasm and smaller cells with hyperchromatic nuclei in the marginal area. Often a clear lymphocytic accompanying infiltrate is present.

Differential diagnosisThis section has been translated automatically.

Leiomyoma; glomus tumor. S.u. ANGLES for other pressure painful tumours of the skin.

TherapyThis section has been translated automatically.

Excision in toto is curative.

Note(s)This section has been translated automatically.

Spiradenomas often occur together with cylindromas, possibly both together with trichoepitheliomas and trichoblastomas (see Brooke-Spiegler syndrome below). Recently, spiradenoma and cylindrome have been regarded as one entity, which are summarized under the term spiradenocylindrome.

LiteratureThis section has been translated automatically.

  1. Eich N et al (1985) The eccrine spiradenoma. dermatologist 36: 240-241
  2. Kersting E, Helwig EB (1956) Eccrine spiradenoma. Arch Dermatol 73: 199-227
  3. Granter SR et al (2000) Malignant eccrine spiradenoma (spiradenocarcinoma): a clinicopathologic study of 12 cases. At J Dermatopathol 22: 97-103
  4. Leonard N et al (2003) Low-grade malignant eccrine spiradenoma with systemic metastases. At J Dermatopathol 25: 253-255

  5. Massoumi R et al (2006) Cylindroma as tumor of hair follicle origin.J Invest Dermatol. 2006 May;126(5):1182-1184

  6. Mirza I et al (2002) Malignant eccrine spiradenoma. Arch Catholic Lab Med 126: 591-594
  7. Rose C (2014) tumors of the scalp. Special aspects of selected examples. Dermatologist 65: 1030-1036
  8. Ter Poorten MC et al (2003) Familial eccrine spiradenoma: a case report and review of the literature. Dermatol Surgery 29: 411-414

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer