Synonym(s)
Palmar filiform hyperkeratosis
DefinitionThis section has been translated automatically.
Very rare, acquired, chronically progressive, disseminated, filiform (spike-like) hyperkeratoses of the palms of the hands and/or soles of the feet, often accompanied by malignancies of internal organs or even of the skin (described is a malignant melanoma).
ManifestationThis section has been translated automatically.
LJ 50-70; no gender preference.
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LocalizationThis section has been translated automatically.
Palms, soles of the feet.
Clinical featuresThis section has been translated automatically.
Mostly multiple, 0.1-0.2 cm large, up to 0.3 cm long, filiform, coarse (spike-like), skin-coloured, indolent papules.
HistologyThis section has been translated automatically.
Sharply limited, columnar hyperkeratosis which may be focally parakeratotic. The underlying epidermis is slightly thinned, otherwise without pathological findings. Dermis without inflammatory infiltrates.
Differential diagnosisThis section has been translated automatically.
Small papular palmoplantar keratoses; porokeratosis plantaris, palmaris et disseminata.
Note(s)This section has been translated automatically.
The clinical picture is considered a paraneoplastic syndrome and has been described in connection with the existence of bronchial carcinoma, renal cell carcinoma, rectal carcinoma, malignant melanoma and chronic terminal renal insufficiency.
LiteratureThis section has been translated automatically.
Bonnecaze AK et al (2016) Keratosis punctata of the palmar creases in a 68-year-old African-American man. BMJ Case Rep bcr2016216050.
Grillo E et al (2012) Spiky keratotic projections on the palms and fingers. Spiny keratoderma. Dermatol Online J 18:8.
Kaddu S et al (1995) Palmar hyperkeratosis: a new paraneoplastic syndrome? J Am Acad Dermatol 33: 337-340.
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Outgoing links (1)
Palmoplantar keratoderma, punctate type 2;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer
