Soti

Definition
This section has been translated automatically.

Acronym for "specific oral tolerance induction". Oral immunotherapy, by which one is able to reduce the risk of anaphylactic reactions.

In oral immunotherapy with native foods, an attempt is made to induce clinical tolerance by oral administration of increasing amounts of the corresponding food. This begins with very small doses, which are increased depending on tolerance. This method shows good results for patients with cow's milk and hen's egg allergy. However, it is not possible to distinguish whether this is a naturally acquired tolerance over time or an induced immune modulation.
Notice! Controlled long-term studies on the effect and side effect rates of SOTI are necessary before clear recommendations for the use of this therapy can be given. Oral immunotherapy is currently not recommended outside of controlled studies.
Similar to subcutaneous immunotherapy, oral immunotherapy also has side effects. The side effects described during oral immunotherapy are usually mild to moderate. Based on the current study situation, regular intake of the food seems to be necessary for some patients to maintain induced clinical tolerance.
Augmentation factors, such as infections or sports, may lower the threshold values during oral immunotherapy and require a corresponding adjustment of the dose.