DefinitionThis section has been translated automatically.
The SLURP1 gene (SLURP1 is the acronym for: Secreted LY6/PLAUR Domain Containing 1) is a protein coding gene
locatedon chromosome8q24
.3. The protein encoded by SLURP1 is a member of the Ly6/uPAR family. SLURP1 is located in the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.
Mutations in this gene are associated with keratosis palmoplantaris transgrediens et progrediens with mutations in SLURP1 (Mal de Meleda), a rare autosomal recessive skin disease.
General informationThis section has been translated automatically.
The SLURP1 protein can be addressed as an epidermal neuromodulator that is important for epidermal homeostasis and inhibition of TNF-alpha release from macrophages, leading to hyperproliferation and inflammatory skin changes. Furthermore, SLURP1 protein possesses antitumor activity. SLURP-1 was found to be a marker of late skin differentiation and is involved in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro, it downregulates keratinocyte proliferation. Furthermore, in T cells, SLURP1 protein is involved in the regulation of intracellular Ca(2+) signaling. It appears to exert an immunomodulatory function in the surface epithelium. SLURP1 is also detected in various biological fluids such as sweat, saliva, tears and urine from normal subjects (Favre B et al. 2007).
LiteratureThis section has been translated automatically.
- Favre B et al. (2007) SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda. J Invest Dermatol 127:301-308.
