Scalloped - cell –Xanthogranuloma

Last updated on: 19.10.2022

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Definition
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Histologic variant of adult xanthogranuloma with predominance of stellate-cephalic macrophages in the fine epithelial substrate.

Manifestation
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Young adults

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Localization
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In one of this retrospective clinicopathologic study, "scalloped -cell -xanthogranuloma" occurred mostly on the back or head and neck of young adult males.

Clinical features
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Yellow or red papules and nodules with a diameter of 0.5-1.0cm. These are usually diagnosed as melanocytic nevi, pigmented fibromas or basal cell carcinomas.

Histology
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Histology characteristically showed a planar infiltrate of predominantly scalloped histiocytes (> 79% of all cell types) in the upper dermis. Other mononuclear (vacuolated, xanthomatized, spindle-shaped, oncocytic) and multinucleated (foreign body and touton) histiocytes were also regularly observed.

Immunohistochemically, cases exhibit a macrophagocytic/dendritic cell lineage, with positivity for CD68, KiM1p, HAM 56, and factor XIIIa .

Ultrastructurally, numerous intracytoplasmic dense, occasionally myeloid corpuscles are found present.

Literature
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  1. Calonje E et al (2020) Cutaneous lymphoproliferative diseases and related disorders. In: McKee's Pathology of the Skin: Xanthoma disseminatum and scalloped cell xanthogranuloma.
  2. Zelger BG et al (1998) Scalloped cell xanthogranuloma. Histopathology 32:368-374.

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Last updated on: 19.10.2022