SART3 Gene

The SART3 gene (SART3 stands for "Spliceosome Associated Factor 3, U4/U6 Recycling Protein") is a protein-coding gene located on chromosome 12q23.3. The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor rejection antigen. This antigen has tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients. Thus, the antigen could be useful for specific immunotherapy.

The SART3 gene product is shown to be an important cellular factor for HIV-1 gene expression and viral replication. It also transiently associates with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. Furthermore, the protein possibly plays a role in hematopoiesis, probably through transcriptional regulation of specific genes, including MYC.

Diseases associated with SART3 include disseminated actinic superficial porokeratosis. Functions associated with this gene include nucleic acid binding and nucleotide binding.

1. Huang M et al. (2018) RNA-splicing factor SART3 regulates translesion DNA synthesis. Nucleic Acids Res 46:4560-4574.
2. Liu P et al (2008) Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3-p31.1. Hum Genet 123:507-513.
3. Timani KA et al (2018) Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma. Mol Cancer 17:124.