Rucinol

Synthetic resorcinol compound used as an active ingredient in the treatment of hyperpigmentation of the skin. Rucinol inhibits tyrosinase, the key enzyme in melanin synthesis. Furthermore it inhibits TRP-1, the tyrosinase-related protein-1. The effect of rocinol on the melanin production seems to be considerably stronger than that of hydroquinone and kojic acid.

hyperpigmentation of the skin; chloasma, lentigo solaris, lentigo senilis

In Germany, cosmetics containing rocinol have been available in the form of serum and cream since January 2005. The effectiveness and tolerance of the substance has been proven by several clinical studies.

1. Khemis A et al (2007) Evaluation of efficacy and safety of rucinol serum in patients with melasma: a randomized controlled trial. Br J Dermatol 156:997-1004
2. Konda S et al (2012 New horizons in treating disorders of hyperpigmentation in skin of color. Semin Cutan Med Surg 31:133-139