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Reader-trélat syndromeL82

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 10.11.2022

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Synonym(s)

Reader-Trelat sign; sign of Reader-Trelat

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HistoryThis section has been translated automatically.

Edmund Leser and Ulyssee Trélat, 1890; Dutchman, 1900

DefinitionThis section has been translated automatically.

Very rare (controversial) paraneoplastic syndrome characterized by acute exanthematous, numerous verrucae seborrhoicae with intense pruritus on non-inflammatory skin.

In about half of the cases the syndrome is associated with acanthosis nigricans maligna (questionable special form). Occurrence mainly in adenocarcinomas of the gastrointestinal tract, less frequently in lymphomas and leukemias.

ManifestationThis section has been translated automatically.

Usually after the age of 50.

TherapyThis section has been translated automatically.

Tumor search and cleanup. If necessary curettage of Verrucae seborrhoicae.

Progression/forecastThis section has been translated automatically.

Bad (corresponding to a mostly advanced tumor growth).

Note(s)This section has been translated automatically.

The joint occurrence of seborrhoeic keratoses and malignancies is not an unusual feature due to the age disposition of both diseases. As reader-Trélat syndrome this clinical constellation can only be addressed if the verrucous changes (possibly +acanthosis nigricans) suddenly appear eruptively.

LiteratureThis section has been translated automatically.

  1. Barth D et al (2015) A Case of Leser-Trélat Syndrome Associated with a Renal Cell Carcinoma. Case Rep Dermatol 7:245-248
  2. Barth G et al (2001) Clinical and histopathological characteristics of early Leser-Trelat syndrome. Dermatologist 52: 649-652
  3. Ceylan C et al (2002) Leser-Trelat sign. Int J Dermatol 41: 687-688.
  4. Constantinou C et al (2010) The sign of Leser-Trelat in colorectal adenocarcinoma. Am Surg 76:340-341
  5. Holländer E (1900) Contributions to the early diagnosis of colorectal carcinoma (heredity relationships and skin changes). Dtsch Med Wochenschr 26: 483-485.
  6. Holländer E (1902) Carcinoma and skin changes. Zentralbl Chir 29: 457-459.
  7. Inamadar AC et al (2003) Eruptive seborrhoeic keratosis in human immunodeficiency virus infection: a coincidence or 'the sign of Leser-Trelat'? Br J Dermatol 149: 435-436
  8. Jepsen RK et al (2014) Leser-Trélat syndrome in malignant mesothelioma and pulmonary adenocarcinoma: is the EGFR pathway part of the syndrome? Virchows Arch 464:117-120
  9. Kovarik CL et al (2005) Forensic dermatopathology and internal disease. J Forensic Sci 50: 154-158.
  10. Patton T et al (2004) Inflammation of seborrheic keratoses caused by cytarabine: a pseudo sign of Leser-Trelat. J Drugs Dermatol 3: 565-566.
  11. Pentenero M et al (2004) Oral acanthosis nigricans, tripe palms and sign of leser-trelat in a patient with gastric adenocarcinoma. Int J Dermatol 43: 530-532
  12. Leser E (1901) Ueber ein die Krebskrankheit bei Menschen begleitendes, noch wenig gekanntes Symptom. Muenchener Med Wochenschr 51: 2035-2036

  13. Schmidt MF et al (2021) Hyperplasia-associated obligate paraneoplasia of the dermatologist 72:295-298.

  14. Stieler W et al G (1986) Acanthosis nigricans and Leser-Trélat sign in double malignancy of stomach and mamma. Z Hautkr 62: 344-366
  15. Wagner G et al (1990) Leser-Trélat syndrome. Akt Dermatol 16: 318-320

Authors

Last updated on: 10.11.2022

Author: Prof. Dr. med. Peter Altmeyer