Reader-trélat syndrome L82

Edmund Leser and Ulyssee Trélat, 1890; Dutchman, 1900

Very rare (controversial) paraneoplastic syndrome characterized by acute exanthematous, numerous verrucae seborrhoicae with intense pruritus on non-inflammatory skin.

In about half of the cases the syndrome is associated with acanthosis nigricans maligna (questionable special form). Occurrence mainly in adenocarcinomas of the gastrointestinal tract, less frequently in lymphomas and leukemias.

The joint occurrence of seborrhoeic keratoses and malignancies is not an unusual feature due to the age disposition of both diseases. As reader-Trélat syndrome this clinical constellation can only be addressed if the verrucous changes (possibly +acanthosis nigricans) suddenly appear eruptively.

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