DefinitionThis section has been translated automatically.
UVA irradiation after local application of methoxsalene as photosensitizer in the form of a cream. Advantages are the lack of systemic NW in external application of Methoxsalen in contrast to peroral therapy (see also PUVA therapy, systemic).
ImplementationThis section has been translated automatically.
Apply Methoxsalen cream ( R162, R164, R163 ) to the affected areas. One hour after applying the cream, irradiation with UVA takes place. Only the affected areas are irradiated. The first dose after MPD, as a rule 0.2-0.3 J/cm2 (depending on skin type) is started. Increase of the UVA dose after 72 hours at the earliest. (delayed phototoxicity); usually by 0.2-0.3 J/cm2 after every 3rd irradiation Frequency of irradiation 3-4 times/week.
Undesirable effectsThis section has been translated automatically.
If the concentration of the methoxsalene is too high or the radiation dose is too high, there is a risk of dermatitis solaris.
Prof. Dr. med. Peter Altmeyer