PSORS9

PSORS9 (PSORS9 stands for psoriasis susceptibility locus 6) is a psoriasis susceptibility locus located in chromosomal region 4q28-32.

Genome-wide linkage scans demonstrated significant linkage (HLOD=4.53, nonparametric linkage (NPL)=4.03 (P=0.000003)) in the D4S2997-D4S3033 marker interval. Evidence for linkage among the families analyzed exceeded genome-wide criteria for significant linkage. Evidence for linkage of PSORS9 with early disease onset of psoriasis was found. This result is in contrast to what was found in the Icelandic population and suggests, among other things, that the Chinese and European populations differ genetically in terms of linkage to PSORS9, which may partially explain the influence of ethnic factors on the differential prevalence of psoriasis (Yan KL et al. 2007).

1. Leder RO et al (1998) Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families. Hum Hered 48:198-211
2. Yan KL et al (2007) Follow-up analysis of PSORS9 in 151 Chinese families confirmed the linkage to 4q31-32 and refined the evidence to the families of early-onset psoriasis. J Invest Dermatol 127:312-318.