Pseudotumour of cutaneous inflammatoryD48.5
Synonym(s)
cutaneous inflammatory pseudotumor; inflammatory myofibroblastic tumor; plasma cell granuloma; Plasma cell granuloma
HistoryThis section has been translated automatically.
Bahadori and Liebow 1973; first description in Haut: Hurt and Santa Cruz 1990;
DefinitionThis section has been translated automatically.
Very rare (only a few cases have been described worldwide), mostly extracutaneous (lung, spleen, lymph nodes) localized, benign, plasma cell-rich (also plasma cell granuloma) pseudolymphoma.
EtiopathogenesisThis section has been translated automatically.
Unknown. Discussed are exclusively inflammatory genesis and infectious causes, e.g. EBV infection.
LocalizationThis section has been translated automatically.
Especially lungs, spleen, lymph nodes, skin (rarely) are affected.
Clinical featuresThis section has been translated automatically.
Clinically typical is a solitary, asymptomatic, red-brown plaque or a corresponding lump with a smooth surface. Rare is a multiple occurrence.
HistologyThis section has been translated automatically.
Dermal nodular infiltrate with lymphocytes, numerous plasma cells and reactive germinal centers (here expression of CD20; CD79a). Isolated eosinophilic and neutrophilic granulocytes. Tendency to fibrosis.
Immunohistology: Polyclonality of the infiltrate.
Differential diagnosisThis section has been translated automatically.
Plasmocytoma, MALT-type extranodal B-cell lymphoma.
TherapyThis section has been translated automatically.
Excision is the treatment of choice.
LiteratureThis section has been translated automatically.
- Bahadori M, Liebow AA (1973) Plasma cell granulomas of the lung. Cancer 31: 191-208
- Buccoliero AM (2003) Plasma cell granuloma--an enigmatic lesion: description of an extensive intracranial case and review of the literature. Arch Pathol Lab Med 127: e220-223
- Hurt MA, Santa Cruz D (1990) Cutaneous inflammatory pseudotumor. Lesions resembling "inflammatory pseudotumors" or plasma cell granulomas" of extracutaneous sites. At the castle catholic 14: 764-773
- Ide F (2000) Plasma cell granuloma of the oral mucosa with angiokeratomatous features: a possible analogue of cutaneous angioplasmocellular hyperplasia. Oral Surg Oral Med Oral Med Oral Pathol Oral Radiol Endod 89: 204-207
- Nakajima T (2001) Cutaneous inflammatory pseudotumor (plasma cell granuloma). Br J Dermatol 144: 1271-1273
- Nonaka D et al (2005) So-called inflammatory myofibroblastic tumour: a proliferative lesion of fibroblastic reticulum cells? Histopathology 46: 604-6013
- Young M (1993) Cutaneous inflammatory pseudotumor: A case report with immunohistochemical and ultrastructural studies. Pathology 25: 405-409