Pseudo-sle syndrome M32.0

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

LLS; lupus erythematosus-like syndrome; Lupus erythematosus visceralis syndrome; lupus-like syndrome; Pseudo-LE Syndrome

Definition
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A clinical picture reminiscent of systemic lupus erythematosus and fulfilling the criteria of the American College of Rheumatology (ACR - Early American Rheumatism Association/ARA) for systemic lupus erythematosus, which occurs after taking certain drugs.

Etiopathogenesis
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Mainly triggered by hydralazine, hydantoin compounds, procainamide, sulfonamides, also Venopyronum. Pseudo-SLE syndrome or lupus-like syndrome occurs under therapy with all approved TNF-alpha antagonists with an estimated incidence of 0.2% (see Biologics).

Clinical features
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Typical skin lesions of systemic lupus erythematosus, frequent fever episodes, occurrence of DNA-Ak, hypocomplementary anaemia, leuko- and thrombocytopenia. Anti-Histon Ak is absent more often.

Indirect immunofluorescence
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ANA neg; detection of antimitochondrial antibodies.

General therapy
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Immediate discontinuation of the medication in question.

Internal therapy
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Short-term high-dose treatment with a glucocorticoid such as prednisolone (e.g. Solu Decortin 100) 150 mg/day i.v., depending on the clinical condition gradual reduction.

Progression/forecast
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The disease usually heals within a period of several months after stopping the medication.

Literature
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  1. Prince JC (2010) Biologics. Dermatologist 61: 668-675

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020