Pseudo-sle syndrome - Altmeyers Encyclopedia

Synonym(s)

LLS; lupus erythematosus-like syndrome; Lupus erythematosus visceralis syndrome; lupus-like syndrome; Pseudo-LE Syndrome

Definition
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A clinical picture reminiscent of systemic lupus erythematosus and fulfilling the criteria of the American College of Rheumatology (ACR - Early American Rheumatism Association/ARA) for systemic lupus erythematosus, which occurs after taking certain drugs.

Etiopathogenesis
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Mainly triggered by hydralazine, hydantoin compounds, procainamide, sulfonamides, also Venopyronum. Pseudo-SLE syndrome or lupus-like syndrome occurs under therapy with all approved TNF-alpha antagonists with an estimated incidence of 0.2% (see Biologics).

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Dermatology

IgA Pemphigus

Very rare, itchy or painful, blister- and pustule-forming autoimmune disease from the pemphigus group with ...

Clinical features
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Typical skin lesions of systemic lupus erythematosus, frequent fever episodes, occurrence of DNA-Ak, hypocomplementary anaemia, leuko- and thrombocytopenia. Anti-Histon Ak is absent more often.

Indirect immunofluorescence
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ANA neg; detection of antimitochondrial antibodies.

General therapy
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Immediate discontinuation of the medication in question.

Internal therapy
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Short-term high-dose treatment with a glucocorticoid such as prednisolone (e.g. Solu Decortin 100) 150 mg/day i.v., depending on the clinical condition gradual reduction.