Proguanil

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Half-life
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2 h

Indication
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The drug of choice for malaria prophylaxis in areas with chloroquine resistance.

Limited indication
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Pregnancy, severe kidney dysfunction (dose reduction).

Dosage and method of use
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  • Adults and young people > 14 years: 200 mg/day p.o.
  • Children/teenagers: 9-14 years: 150 mg/day
  • Children: 5-8 years. 100 mg/day.
  • Children: 1-4 y. 50 mg/day.
  • children: < 1 year: 25 mg/day.

Remember! To be taken in combination with 200 mg chloroquine per day. Start at least 24 hours before arrival in the endemic area until 4 weeks after leaving the area!

Undesirable effects
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Anemia, gastrointestinal problems, hematuria, allergic skin reactions.

Interactions
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Stomatitis may occur if chloroquine is administered at the same time.

Preparations
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Paludrine

Incoming links (2)

Atovaquone/proguanil; Malaria;

Outgoing links (3)

Antimalarials; Chloroquine; Stomatitis;

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Last updated on: 29.10.2020