Synonym(s)
Cutaneous cytotoxic gamma-delta positive T-cell lymphoma; Cutaneous cytotoxic T-cell lymphoma gamma-delta positive; Cutaneous cytotoxic T-cell lymphoma (gamma-delta positives); Cytotoxic (gamma-delta positive) cutaneous T-cell lymphoma
DefinitionThis section has been translated automatically.
Since 1994 recognized lymphoma entity (REAL classification) with predominantly systemic manifestations. Very rarely skin infestation (about 3% of cutaneous T-cell lymphomas). By definition, tumor cells express the gamma-delta T-cell receptor on the surface.
Occurrence/EpidemiologyThis section has been translated automatically.
More common in organ transplants, in patients with Hodgkin's disease or lupus erythematosus in the medical history.
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ManifestationThis section has been translated automatically.
In younger patients (average age in larger studies: 34 years).
Clinical featuresThis section has been translated automatically.
Clinic similar to mycosis fungoides or pagetoid reticulosis. A described subcutaneous form of gamma-delta positive cutaneous T-cell lymphoma is similar in course to panniculitis-like cutaneous T-cell lymphoma. Systemic infestation is frequent, especially in the liver, spleen and upper intestinal tract.
TherapyThis section has been translated automatically.
Progression/forecastThis section has been translated automatically.
Poor prognosis; mean survival time for systemic infestation = 16 months. Poor response to chemotherapy.
LiteratureThis section has been translated automatically.
- El-Shabrawi-Caelen L et al (2000) The clinicopathologic spectrum of cytotoxic lymphomas of the skin. Sem Cutan Surg 19: 118-123
- Guizzardi M et al (2003) Cytotoxic gamma/delta subcutaneous panniculitis-like T-cell lymphoma: report of a case with pulmonary involvement unresponsive to therapy. J Eur Acad Dermatol Venereol 17: 219-222
- Jaffe ES et al (2003) Classification of cytotoxic T-cell and natural killer cell lymphomas. Semin Hematol 40: 175-184
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Incoming links (1)
PTCL;Outgoing links (6)
Cutaneous t-cell lymphomas; Hodgkin's lymphoma, skin manifestations; Lupus erythematosus (overview); Mycosis fungoides; Pagetoid reticulosis; Subcutaneous panniculitis-like t-cell lymphoma;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer